陈苏——技术研发(分析化学、脂类化学、神经药理学)

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专家姓名陈 苏性  别 男
学  历 博士学位年  龄 48
职  务 CEO and Research Director所在地区 美国(USA)
技术职称 其他职称特殊称号 
专业方向 分析化学;色谱学;质谱学;脂类化学; 脂类生物化学;神经药理学
所在单位 ChainOn Biotechnology INC.
技术服务技术问答;产品销售;科学研究合作

 
 
个人介绍
美国QUEST疾病诊断公司, NICHOLES 研究所, 生物化学基因部副主任;
美国加利福尼亚州; (2002 – 2005);
美国RUSH大学医学院, 药理系, 助理教授, 美国芝加哥 (1998 – 2002);
英国WARICK大学化学系,高级研究员, 英国COVENTRY市 (1992 – 1997);
意大利国家研究院, 帕多瓦分部, 博士后研究; 意大利帕多瓦市; (1990 – 1992);
学历:
意大利米兰MARIO NEGRI药理研究所, 环境药理和毒理系,
获博士学位 (毒理分析学) (1986 – 1990);
发表约35篇文章 (英文); 两个美国专利和一个中国专利
LIST OF SELECTED PUBLICATIONS
Lipid Chemistry and Biochemistry
Su Chen, Fei Huang and Hazel Lum, Identification of biologically active dicarboxylic acid-containing diacyl phosphatidylcholine species; (Submitted to J .Lipid Res.2006);

Su Chen, P. M. Carvey and K. W. Li, Characterization of the molecular species of phosphatidylethanol-amines from kidney of the fresh water snail lymneae stagnalis by mass spectrometry; (1999) Rapid Communi. Mass Spectrom. 13, 2416-2423.

Su Chen, Tandem mass spectrometric approach for determining structure of molecular species of aminophospholipids; (1997) Lipids 32, 85-100.

Su Chen and K. W. Li, Negative ion liquid secondary ion and tandem mass spectrometric analysis of the molecular species of aminophospholipids as 9-fluorenylmethyloxycarbonyl derivatives; (1996) Anal. Chim. Acta 326, 127-140.

Su Chen and M. Claeys, Characterization of omega-3-docosahexaenoic acid-containing molecular species of phospholipids in rainbow trout liver; (1996); J. Agr. Food Chem. 44, 3120-3125.

M. Claeys, H. Van den Heuvel, Su Chen, P. J. Derrick, F. A. Mellon and K. R. Price, Comparison of high- and low-energy collision-induced dissociation tandem mass spectrometry in the analysis of glycoalkaloids and their aglycons; (1996) J. Am. Soc. Mass Spectrom. 7, 173-181.

Su Chen, Characterization of isopropyl derivatives of monosialogangliosides by liquid secondary ion mass spectrometry and tandem mass spectrometry; (1995) Anal. Lett. 28, 1275-1286.

Su Chen and M. Claeys, Approach to the large-scale preparation of highly pure phosphatidylserine from bovine brain; (1995) J. Chromatogr. B: Biomedical Applications 666, 178-182.

Su Chen and K. W. Li, Structural analysis of underivatized and derivatized aminophospholipids and phosphatidic acid by positive ion liquid secondary ion and collisionally induced dissociation tandem mass spectrometry; (1994) J. Biochem. 116, 811-817.

Su Chen, Partial characterization of molecular species of phosphatidylserine from human plasma by high performance liquid chromatography and fast atom bombardment mass spectrometry; (1994) J. Chromatogr. B: Biomedical Applications 661, 1-5.

Su Chen, P. J. Derrick, F. A. Mellon and K. R. Price, Analysis of glycoalkaloids from potato shoots and tomatoes by four-sector tandem mass spectrometry with scanning-array detection: Comparison of positive ion and negative ion methods; (1994) Anal. Biochem. 218, 157-169.

Su Chen, G. Menon and P. Traldi, Identification of aminophospholipid stereomers by positive ion fast atom bombardment combined with collisional activation mass-analyzed ion kinetic energy analysis and high performance liquid chromatography; (1992) Org. Mass Spectrom. 27, 215-218.

Su Chen, O. Curcuruto, S. Catinella, P. Traldi and G. Menon, Characterization of the molecular species of glycerophospholipids from rabbit kidney: An alternative approach for the determination of the fatty acyl chains position by negative ion fast atom bombardment combined with mass-analyzed ion kinetic energy analysis; (1992) Biol. Mass Spectrom. 21, 655-666.

Su Chen, G. Pieraccini and G. Moneti, Quantitative analysis of the molecular species of monosialogangliosides by continuous-flow fast atom bombardment mass spectrometry; (1991) Rapid Communi. Mass Spectrom. 5, 645-648.

Su Chen, G. Kirschner and P. Traldi, Positive ion fast atom bombardment mass spectrometric analysis of the molecular species of glycerophosphatidylserine; (1990) Anal. Biochem. 191, 100-105.

Su Chen, R. Mariot, G. Kirschner, D. Favretto and P. Traldi, Analysis of arachidonic acid-containing molecular species in glycerophospholipid classes from rat kidney by fast atom bombardment mass spectrometry; (1990) Rapid Communi. Mass Spectrom. 4, 495-497.

Su Chen, G. Kirschner and E. Benfenati, Quantitative analysis of 1-stearoyl-2-oleioyl-glycero-3-phosphoserine by negative ion fast atom bombardment mass spectrometry; (1990) Rapid Communi. Mass Spectrom. 4, 214-216.

E. Benfenati, G. De Belis, Su Chen, L. Bettazzoli, R. Fanelli, M. T. Tacconi, G. Kirschner and G. Page A fast atom bombardment mass spectrometric method to quantitate lysophosphatidylserine in rat brain; (1989) J. Lipid Res. 26, 1983-1986.

Su Chen, E. Benfenati, R. Fanelli, G. Kirschner and F. Pregnolato, Molecular species analysis of phospholipids by negative ion fast atom bombardment mass spectrometry: Application of the surface precipitation technique; (1989) Biomed. Environ. Mass Spectrom. 18, 1051-1056.

Peptide Chemistry

F. A. Van Golen, K. W. Li, Su Chen, C. R. Jimenez, and W. P. M. Geraerts, Various isoforms of myomodulin identified from the male copulatory organ of Lymnaea show overlapping yet distinct modulatory effects on the penis muscle; (1996) J. Neurochem. 66, 321-329.

K. W. Li, R. M. Hoek, F. Smith, C. R. Jimenez, R. C. Van der Schors, P. A. Van Veelen, Su Chen, J. Van der Greef, D. C. Parish, P. R. Bebjamin and W. P. M. Geraerts, Direct peptide profiling by mass spectrometry of single identical neurons complex neuropeptide processing pattern; (1994) J. Biol. Chem. 269, 30288-30292.

Ron Self, D. A. Stead, S. P. Robins, P. J. Derrick and Su Chen, Analysis of Pyridinoline and its derivatives by scanning-array four-sector tandem mass spectrometry; (1994) Rapid Communi. Mass Spectrom. 8, 99-104.

S. Evans, R. Buchanan, A. Hoffman, F. A. Mellon, K. R. Price, F. Walls, S. Hall, A. Burlingame, Su Chen and P. J. Derrick, Structural characterization of a glycoalkaloid at the femtomole level by means of four-sector tandem mass spectrometry and scanning-array detection; (1993) Org. Mass Spectrom. 28, 289-290.

Pharmaceutical Chemistry

Chunyan Hao, Raymond E. March, Timothy R. Croley, Su Chen, M. Glenn Legault, and Paul Yang, Study of the neurotransmitter dopamine and neurotoxin 6-hydroxydopamine by electrospray ionization coupled with tandem mass spectrometry; (2002) Rapid Communi. Mass Spectrom. 16, 591-599.

Su Chen and P. M. Carvey, Validation of liquid-liquid extraction followed by flow-injection negative ion electrospray mass spectrometry assay to Topiramate in Human Plasma; (2001) Rapid Communi. Mass Spectrom. 15, 159-163. Su Chen and P. M. Carvey, Rapid approach to the quantitative determination of Topiramate in human plasma by liquid-liquid extraction and flow-injection negative ion electrospray mass spectrometry; (1999) Rapid Communi. Mass Spectrom. 13, 1980-1984.

Su Chen, Q. Li, P. M. Carvey and K. W. Li, Analysis of 9-fluorenylmethyloxycarbonyl derivatives of catecholamines by high-performance liquid chromatography, liquid chromatography/mass spectrometry and tandem mass spectrometry; (1999) Rapid Communi. Mass Spectrom. 13, 1869-1877.

R. Mariot, L. Zangirolami, P. Bellato, Su Chen, G. Pieraccini and G. Moneti, Quantitative determination of a coumarine derivative, cloricromene acid, in rabbit plasma and platelets; (1992) J. Chromatogr.B: Biomedical Applications 576, 143-148.

D. K. Lin, Su Chen, J. W. Ma and Z. P. Sun, Identification of the two major components in Chinese Nystatin; (1986) Acta Pharmaceutica Sinica 21, 454-457.

D. K. Lin, Y. Chou and Su Chen, Studies on the structure of the major component of Vancomycin made in China; (1986) Acta Pharmaceutica Sinica 21, 208-212.

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